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Groups 4, 5, 6, 7: These groups were received IP injection of vitamin B 12 at doses of 25, 50, 100 and 200 g kg -1 , respectively, for 10 consecutive days after surgically-induced crush injury in tibial nerve and served as crush plus vitamin B 12 groups

This could then be followed by one of the following: (1) three to six daily intramuscular injections of 1 mg of cobalamin, (2) intramuscular injection of 1 mg vitamin B12 at weekly intervals for 1 month, or (3) several weeks of very high-dose oral therapy (2 mg cobalamin daily)