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In another study, based on the fact that individuals residing at high altitudes have a reduced prevalence of type 2 diabetes mellitus, Shepherd and colleagues investigated the impact of repeated nocturnal normobaric hypoxic exposure on glycemic regulation, appetite, gut microbiota, and inflammation in persons with type 2 diabetes mellitus 84

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Insulinotropic and antidiabetic effects of 17-estradiol and the GPR30 agonist G-1 on human pancreatic islets