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In the last decade, significant new data have accumulated lending support for an underlying, early cytodegenerative process of unknown nature that exhibits remarkable similarities to other neurodegenerative disorders

They can then advise on a suitable treatment plan, which typically focuses on addressing the anemia directly.

(2020b) identified eEANs in contact with intestinal epithelial cells can detect microbes and their metabolites, specifically SCFAs, bile acids, and neuropeptides, via vagal afferents and subsequently sympathetically modulate gut activity via a CNS-directed circuit (Muller et al., 2020b)

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