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Efficacy and safety of immune checkpoint inhibitors for EGFR mutated non-small cell lung cancer: a network meta-analysis

A study conducted on a non-Caucasian Algerian population was the first to demonstrate the genotypic association between an intronic variant in the IP6K3 gene and a reduced risk for HT

Other pathways involve Src-Family Kinases, p38 MAPK, PINK1-Mediated Mitophagy, and Hippo-YAP signaling pathway

Our identification of VRK2-mediated SLC7A11 trafficking suggests a potential immune evasion mechanism, as SLC7A11-high tumors often display T cell exclusion phenotypes [37], warranting future investigation into whether VRK2 expression could predict therapeutic response to combined ferroptosis inducers and immune checkpoint inhibitors