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The result remained consistent (MR-PRESSO, p = 0.021) (Figure 5) after excluding 1 outlier SNP (rs4588066)

All randomized controlled trials incorporated Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium species, and the aggregated results remained statistically significant following the leave-one-out sensitivity analysis [180]

This is because it is water-soluble, so most ingested B12 is actually flushed out in the urine

Taken together, we propose a model in which increased oxidative stress in TTR-V30M carriers, potentially promoted by misfolded TTR, contributes to reduced GSH availability [49, 50]