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Some work in water-based environments (like glutathione), some in fat-based environments (like astaxanthin), and some in specific organs

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5.2 Influence of altered mitochondrial dynamics on inflammation Altered mitochondrial dynamics, which include the processes of mitochondrial fission, fusion, biogenesis, and mitophagy, play a critical role in regulating cellular homeostasis and can significantly influence inflammatory responses (Mills and ONeill, 2016)

Yes, it is essential to inform your GP or prescribing clinician before adding berberine to your regimen