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Within this context, it is not surprising that a great deal of inhibitors and pro-drugs targeting GSTs have been synthesized and tested so far, with new scaffolds or analogues being reported every year

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In that year and 2023, the FDA and European Medicines Agency (EMA) approved sodium thiosulfate (PEDMARK and Pedmarqsi, respectively) therapy for reducing cisplatin ototoxicity in children suffering from non-metastatic solid tumours [77,78,79,80]

The aim of this study is to investigate possible CBD neuroprotective effects in the development of parkinsonism induced by low-dose repeated reserpine, using two approaches: (1): administering CBD concurrently with the development of parkinsonism (concomitant treatment), and (2) using CBD as a preventive treatment before the induction of the parkinsonian alterations (preventive treatment)