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In the same experiment, IGF-1 concentrations apparently rose from baseline values of about 90100 g/L to approximately 150160 g/L after the extended 24-hour GHRP-2 exposure

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A novel role for 12/15-lipoxygenase in regulating autophagy

Initially described as a pro-atherogenic molecule due to its proliferative role in VSMC, it was further demonstrated that the effect of IGF-I on VSMC was to compensate for local apoptosis, and that, overall, IGF-I is not pro-atherogenic in native arteries but anti-atherogenic[320], mainly through enhanced nitric oxide production[308]