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[DOI] [PubMed] [Google Scholar] 106.de Quay B., Malinverni R., Lauterburg B.H

10.1038/nrendo.2011.153 Nat
small clinical trials = phase II

[2][3] Because of its significant effect on growth and development as well as causing associated medical problems and reduced quality of life, childhood-onset GHD has been treated with replacement therapy for more than 30 years