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Retinol remains stable and effective at a slightly acidic to neutral pH of 5.5-6.5
There is also variable contribution from T-helper type 1 (Th1) driven pathways, including interferon-gamma (IFN-) and interleukin 12 (IL-12), as well as T-helper type 17 (Th17) and T-helper type 22 (Th22) cells [25]
