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Effect of iodine nutrition during pregnancy and lactation on child cognitive outcomes: a review

One of the key mechanisms underlying the dark and shrunken morphology of granule cells in the DG during epileptic episodes is excitotoxicity, primarily mediated by excessive glutamate release (Wang and Qin, 2010)
Other endogenous substances that inhibit AKRs, particularly, AKR1B10 include steroid hormones, bile acids, isolithocholic acid, and androst-4-ene-3,6-dione [175,176]