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The brains of the mice were removed, frozen, and embedded in Optimal Compound Temperature compound (Sakura Finetek, USA)

PERIOD2 is a circadian negative regulator of PAI-1 gene expression in mice

Symptoms of actual copper toxicity (nausea, vomiting, abdominal pain, liver damage) require far higher exposures than any GHK-Cu protocol provides

Other ongoing investigations with semaglutide include the treatment of non-alcoholic fatty liver disease (NASH) and its use in an oral formulation for the treatment of T2D
