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or (iii), invoking alternative desaturation mechanisms: certain hepatic and pulmonary carcinomas redirect palmitate toward sapienate formation a route that yields a monounsaturated product without the input of stearoyl-CoA desaturase-1 and thus with a reduced oxygen burden 316

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Clinical metabolomic studies in peritoneal dialysis patients further demonstrate increased PCS and TMAO alongside reduced SCFAs, supporting the concept of a toxin accumulationSCFA depletionbarrier dysfunctionsystemic inflammation cascade (50)

Shih, J