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Translational perspective: Targeting regulated cell death pathways in myocardial IRI offers multiple pharmacological entry points, ranging from upstream modulation of nutrient- and stress-sensing pathways (e.g., mTOR, AMPK, PARP-1, inflammasome components) to downstream inhibition of executioner mechanisms, such as lipid peroxidation, membrane rupture, and inflammatory caspase activation

The sp 3 carbon scaffold of the pinane rings offered an effective way to capture interactions with the hydrophobic portions of subpocket C while also displacing likely trapped waters

(Originally, the main symptom was excessive sweet urine, known as glycosuria)