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Rare allergic reactions (particularly in individuals sensitive to sulfa, due to methionine)

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According to long-term safety data published in NIH journals tracking patients for up to 10 years, the most common side effects include headache (19%), injection site reactions (8%), back pain (5%), and fatigue (5%)all typically mild and transient. Safety Profile Comparison: The FDA safety review found that serious adverse events occurred in only 7% of patients over extended treatment periods, with most unrelated to Nucala severe asthma therapy