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& Neeland, I
B 37 LaurentF.SaivinS.ChretienP.MagnavalJ
Tumors simultaneously rewire antioxidantsactivating NRF2 and elevating GSH/thioredoxin systemscreating a narrow therapeutic window in which pushing ROS beyond buffering capacity triggers apoptosis or ferroptosis, whereas indiscriminate scavenging blunts therapy and fosters resistance (Reczek and Chandel 2017)
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