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Brown or black pigmentation spreading from the nail bed, matrix and nail plate to the adjacent cuticle and proximal or lateral nail folds (Hutchinsons sign) is a crucial clinical clue to diagnose or exclude melanoma[78]
doi: 10.3390/ijms19123851 42 ZhuJVan den EyndeB
[DOI] [PubMed] [Google Scholar] 50.Malaguarnera M., Gargante M.P., Cristaldi E., Colonna V., Messano M., Koverech A., Neri S., Vacante M., Cammalleri L., Motta M
