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Paradoxically, the finding by Lobry showed that activation of the NOTCH signaling pathway induced cell cycle arrest and apoptosis in LSCs with MLL-AF9 fusion, in part due to Tet methylcytosine dioxygenase 2 (TET2)-mediated epigenetic alterations (58)

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So, ideally, you would want to stop six weeks before your surgery, she says

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