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Beyond its effects on the central nervous system, DSIP has been detected in peripheral organs, blood, cerebrospinal fluid, and even human breast milk, indicating a systemic physiological role
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However, years before, Aguila [83] argued that the hypothalamic increase in NO induced by GHRH would act on SS neurons increasing both the synthesis and release of SS
The APE1 inefficiently cleaves but recruits various transcription factors to activate downstream genes, such as vascular endothelial growth factor (VEGF) and endonuclease IIIlike protein 1 (NTHL1) [95]
