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Description
A new immunometabolic perspective of intervertebral disc degeneration

A attracts and activates microglia and astrocytes, leading to the release of pro-inflammatory mediators such as TNF, IL-6, IL-2, and IL-1, as well as reactive oxygen and nitrogen species produced by oxidative stress, which ultimately leads to neuronal cell death (35)

mTOR- and HIF-1mediated aerobic glycolysis as metabolic basis for trained immunity

Our findings demonstrate that l-CIT attenuates aortic blood pressure and wave reflection responses to exercise-related metabolites
