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By reducing SAM consumption through NNMT inhibition, 5-Amino-1MQ helps preserve methylation capacity for other critical cellular processes, including DNA and histone methylation (epigenetic regulation), neurotransmitter synthesis, and phospholipid metabolism

10.1016/j.mehy.2003.12.045 Medical Hypotheses 83 TahirM.NawrockiA.DitzelH

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Earlier research work used candidate gene studies or individuals with either familial history of psychosis spectrum disorders or schizotypal personality disorder as a proxy for elevated genetic risk for psychosis and different environmental stressors to investigate gene-environment interaction