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[DOI] [PMC free article] [PubMed] [Google Scholar] 116.Rzem R, Vincent MF, Van Schaftingen E, Veiga-da-Cunha M

[] Although the clinical manifestations caused by the toxic effects of various heavy metals are fairly diverse and commonly non-specific, the majority of these metals cause harm through similar processes, usually by substituting other elements in biochemical reactions or causing physiological alterations by binding to important enzymes

The environment can also alter DNA methylation or histone modifications, regulating the expression of inflammatory genes and enhancing the innate immune response ( Figure 2 )

Joint hypermobility Syndrome: recognizing a commonly overlooked cause of chronic pain