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Zuo et al., 2020
With short-acting opioids, withdrawal symptoms often become severe within 1-3 days

Each time a cell divides, telomeres shorten, eventually triggering cellular senescence or apoptosis - effectively limiting the replicative lifespan of normal somatic cells to approximately 50-70 divisions (the Hayflick limit)

1A), further confirming the undifferentiated state of the cells