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Pyrazinamide (PZA) 2000 mg/day was added in August 2021, and after two weeks on PZA, he was instructed to go on high dose pulsed dapsone combination therapy (HDDCT), at 200 mg PO BID 4 days for his resistant symptoms, along with increasing doses of methylene blue (working up from 50 mg BID to 100 mg BID) with Leucovorin 75 mg/day and L-methyl folate 45 mg/day

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Proteomics 79, 8799

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As shown (Figure 5A), the fluorescence intensity of H2AX signals, an indicator of DNA damage, was considerably increased in aged oocytes in comparison with fresh controls

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