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Description
These are peptide molecules that have been synthesized in a laboratory that stimulate the release of growth hormone and thereby stimulate the production of IGF-1
The study established that FOXO4 maintains senescent cell viability by targeting p53 to the nucleus and preventing apoptosis, and that disrupting the FOXO4-p53 interaction with FOXO4-DRI causes p53 nuclear exclusion and cell-intrinsic apoptosis in ionising radiation-induced and doxorubicin-induced senescent IMR90 fibroblasts

This is a direct consequence of slowed gastric emptying and increased gastrointestinal transit time

[PMC free article: PMC5878302] [PubMed: 29592996] [CrossRef] 219
