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VEGF-A, a representative key regulator of angiogenesis under physiological and pathological conditions 2 , binds to VEGF receptor 2 (VEGFR2) during the early process of VEGF-A signaling, resulting in its phosphorylation and internalization via endocytic vesicles, followed by the activation of PLC1 3,4
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Notably, in the treatment of CD19-malignancies, CRS typically occurs more than 24 hours after CAR-T-cell infusion [23]