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When tested in normal human volunteers, it was found to exert sedative properties, but when tested in ~500 patients with various psychiatric disorders, only those with endogenous depression exhibited a remarkable improvement of clinical symptoms after 1-6 weeks of daily treatment

It is responsible for balancing two hormones (calcitonin and PTH) that stimulate calcium absorption and resorption

LL-37 in particular also promotes gingival keratinocyte migration and angiogenesis accelerating the repair of damaged gingival tissue alongside its antimicrobial function

It sits in the membranes of keratinocytes and fibroblasts (the two main cell types responsible for skin structure and barrier function), and it pulls ergothioneine in from both the bloodstream and, when applied topically, from the surface