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GLP-1 receptor agonists caused thyroid C-cell tumors in rodent studies, and while human cases are rare, the FDA requires a black-box warning
The peptide Herdegradin, which downregulates EGFR, stimulates mitophagy through the mTORC2/Akt pathway, effectively inhibiting the growth of EGFR-positive cancers, such as PCa, ultimately inducing the death of PCa cells (Xiong et al., 2020)

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