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(2014, 2018) have proposed that BPC-157s interaction with the nitric oxide system which appears to be bidirectional, counteracting both NO deficiency and NO excess depending on the experimental context may serve as a central organising mechanism for many of these cytoprotective observations

ECG Recording ECGs were recorded continuously in deeply anesthetised rats for all three main leads, by positioning stainless steel electrodes on all four limbs using an ECG monitor with a 2090 programmer (Medtronic, Minneapolis, MN, USA) connected to a Waverunner LT342 digital oscilloscope (LeCroy, Chestnut Ridge, NY, USA) after 30 min of ligation