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In most organs and tissues of patients with diabetes and also animal models of diabetes, excessive mitochondrial ROS production is observed, while other mitochondrial abnormalities, including impaired mitochondrial biogenesis and OXPHOS, disordered mitochondrial dynamics, and mitophagy, are tissue-specific [114]

Zhang W., Zeng L., Yu H., et al., Injectable Spontaneous Hydrogenreleasing Hydrogel for Longlasting Alleviation of Osteoarthritis, Acta Biomaterialia 158 (2023): 163177

Characterisation of AZD6234, a novel amylin receptor selective agonist peptide, in rodent models of weight loss and aversion, (accessed: September 2025)

Authored by: Sergey Terushkin, MD, FACS, FASMBS, DABOM, DABS-FPMBS Key Takeaways When you start a powerful metabolic medication like Mounjaro (Tirzepatide) or Zepbound , you expect certain changes