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374 Similarly, Lycium barbarum polysaccharides exert a protective effect by inhibiting the mTOR/p70S6K pathway, promoting autophagy in Schwann cells

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Research shows that in senescent cells, p53 levels are maintained low through ubiquitination while its pro-apoptotic activity is repressed through nuclear segregation by FOXO4. The peptide's competitive inhibition restores p53 activity by promoting nuclear exclusion, allowing p53 to execute its pro-apoptotic program and eliminate senescent cells through targeted pathway activation

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