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Due to decreased phosphorylation and inhibition of FOXO1, TSC-deficient mice have increased gluconeogenic genes, Pepck and Igfbp , both targets of FOXO1 (354)

5 The actual incidence of liver injury by statins is considered to be much lower than general aminotransferase abnormalities, around 1%

J Neurochem 134:8696 Kuratsune H, Watanabe Y, Yamaguti K, Jacobsson G, Takahashi M, Machii T, Onoe H, Onoe K, Matsumura K, Valind S, Kitani T, Langstrom B (1997) High uptake of [2-11C]acetyl-l-carnitine into the brain: a PET study

Lipid peroxidation refers to a series of biochemical events triggered by the action of ROS on the unsaturated fatty acids in cellular and subcellular membranes