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Area under curve The AUC were approximated by simple integral (alike to trapezoidal integration) where the first term defines a rectangle and second term denies a tringle 24

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Choice B: Effective penetration into the liver is a necessary pharmacokinetic property for drugs treating hepatic infections

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In Supplementary Note 2 we derive a summary-level version of the second stage following the approach introduced in the multivariate imaging-wide association study (MV-IWAS) method 14,16 , which is related to other methods in the field of Mendelian randomization 87,88

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