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Description
Sometimes pagetoid spread can be very marked and involve almost the entire lesion such melanocytic proliferation is generally referred to as a melanocytic acral nevus with intraepidermal ascent of cells (MANIAC) ( Fig
Pediatr Blood Cancer 46(1):6671 Levin AV, Stroh E (2011) Albinism for the busy clinician

ROS and RNS production in physiological conditions is maintained at low levels [25, 26] and used to regulate various physiological functions, including cell signaling, homeostasis, vascular tone, and immune reactions [27]

This challenge is further compounded across certain categories of CAIM