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In a neonatal piglet-based ARDS model, it was found that experimental supplementation with phosphatidylglycerol reduced interleukin-6 (IL-6) and alveolar apoptosis while preserving the alveolar-capillary barrier, thereby reducing pulmonary edema

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In addition, the use of salsalate alone in the high fat diet of type 2 diabetic rats provided only minimal protection/improvement of vascular and neural dysfunction

Ethics declarations Ethics approval Both preclinical studies of NVS1 were conducted in compliance with the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals, and the Office of Laboratory Animal Welfare and in accordance with the Novartis Animal Care and Use Committee (NACUC)