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Other early pioneers of the theory that free radicals lead to cataract formation include: The Bhuyans, primarily using animal models in New York

In these ways, IH induces abnormal vasoconstriction and elevates systemic blood pressure

In the brain itself, changes are less severe: they occur as small sources of nervous fibers decay and accumulation of astrocytes, usually subcortically located, an also round hemorrhages with a torus of glial cells

Moreover, it should be noted that the accumulation of fructose has been suggested to be more deleterious than that of glucose [75, 81] as fructose metabolism by fructokinase bypasses key-regulated steps of the glycolytic pathway [82] and thus can deplete intracellular phosphate and ATP, thereby inducing oxidative stress and inflammation [83]