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A separate ligament study (Cerovecki et al., 2010, Journal of Orthopaedic Research ) reported improved medial collateral ligament healing in rats over 90 days post-transection, with effective dosing observed across intraperitoneal, oral, and topical routes

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There was increased tight junction protein expression (e.g., zonula occludens-1 (ZO-1)) and transepithelial resistance, which significantly mitigates leaky gut syndrome and stabilizes cellular junctions [18]

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