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They are much less efficient and have even been found to have no efficiency in providing some of the benefits glutathione is used to produce
Agrawal R, Ahuja J, Strange CD, Price MC, Shroff GS, Truong MT

Smith L, Camerino PW (1963) Comparison of polarographic and spectrophotometric assays for cytochrome c oxidase activity*

While this approach is appropriate for capturing early oxidative and micronutrient-related alterations associated with disease severity, it does not allow evaluation of temporal dynamics, recovery patterns, or causal relationships, which would require longitudinal follow-up
