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Journal of molecular biology , 243 (5), 906918

Main advantages of magnetic beads for biotin-binding: If your target protein or ligand needs to be covalently coupled, use surface-activated beads Different ligands (antibodies, proteins, etc.) require different bead surface properties and immobilization chemistries

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Viral gene transfer of Cbs to replace Cbs in Cbs -heterozygous gene-deficient mice is a nice touch and eliminates variables imposed by dietary manipulation
