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These data, together with the identification of the catalytic residues, indicate that SapM behaves as an atypical alkaline phosphatase with broad monoesterase activity

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Cell Metab (2017) 26(3):558567e5

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Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction

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Hence, GSH treatment may be an effective way to combat endothelial cell dysfunction, promote BBB function and maintain vascular health

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