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Methods in Molecular Biology (Methods and Protocols)

History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

Another potential side effect is headaches, which are usually mild and of short duration

Method Development of an In Vitro Vertical Franz Diffusion Cell System to Assess Permeation of Cosmetic Active Ingredients