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However, CagriBB has equivalent potency to Cagri, in CRE-reporter assays in mammalian cells expressing AMY 3 Rs (Supplementary Table 4), suggesting there is negligible impact of this rotamer difference

And what it was able to do was assemble so much information from tens of thousands of other clinical trials, from meta analysis and from a microbiological data and say if you expose this cell to this compound in this media, this is going to be the result
The inflammation is reduced

benefits are generally greatest when B12 or other nutrient status is genuinely low
