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In addition, inhibition of the CISD2 gene in HNC cells increases the accumulation of mitochondrial iron and lipid ROS, thereby promoting the occurrence of ferroptosis 58

Regular exercise may enhance OA outcomes by aiding in weight loss and decreasing joint loading (171), decreasing systematic inflammatory biomarkers (such as IL-6 associated with cartilage degradation) (172), and providing appropriate loading of articular cartilage, which is essential for preserving tissue integrity (173)

BMB Rep 53(10):539544

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