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The occurrence and development of different diseases are associated with abnormal GSH metabolism through different mechanisms: Glutathione dynamics during sepsis Sepsis is characterized by severe redox imbalance, and glutathione plays a key role in combating oxidative and nitrosative stress

PPARa Regulates the FSP1-CoQ10-NAD(P)H Pathway to Protect Neurons from Ferroptosis in TSCI Mice, Promoting Neuronal Survival and Motor Function Recovery Having confirmed that PPARa regulates FSP1 transcription and mitigates lipid peroxidation through the FSP1-CoQ10-NAD(P)H pathway in vitro, we sought to determine whether this mechanism could improve neuronal survival and functional recovery following TSCI in vivo

However, excessive iron overload leads to mitochondrial damage, induces further mitochondrial autophagy, and provides an additional source of iron for lipid peroxidation

[iii] ITV News 29th June 2023