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It can be linked with: Pregnancy Lack of exercise A sudden change in diet A diet with not enough fibre Having to stay in bed for a long time Medicines such as morphine or codeine Loss of 'tone' of the bowel muscles in older people Whatever the cause, constipation can be uncomfortable

The concentration of -synuclein in these condensates can reach to as high as 3040 mM ( in vitro conditions is guided by the Vesicle Associated Membrane Protein 2 (VAMP2) and its interaction with R-SNARE (Sawner et al., 2021)

Treatments are carried out exclusively at our Cockfosters clinic, ensuring the highest standards of care and comfort

Importantly, Firmicutes, a phylum that includes Clostridium , exhibits a negative correlation with the SLE disease activity index (SLEDAI) (148, 149)