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The skin acts as a reservoir, allowing the peptide to remain active in the local tissue for many hours, creating a prolonged local effect instead of a short systemic one

doi:10.3390/antiox12071316 Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA

Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimers disease markers in subjects with mild cognitive impairment