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In the MCAO mouse model of ischemic stroke, BHB was shown to activate HCA2 in macrophages that infiltrate the brain after injury and the protective effect of the KD and BHB was lost in HCA2 knock-out mice
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* 5 HMB, -hydroxy--methylbutyrate
SOD Gene Expression and Regulatory Mechanism Deletion of SOD1 in yeast and mice leads to widespread cell and genomic DNA oxidative damage [25,26]
