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Interventions to modulate NAD + levels Several strategies have been developed to modulate NAD + metabolism, both for mechanistic investigation purposes and to assess their potential therapeutic effects to improve health in aging or disease

Cofactor for L-methylmalonyl-coenzyme A mutase 5-Deoxyadenosylcobalamin is required by the enzyme that catalyzes the conversion of L-methylmalonyl-coenzyme A to succinyl-coenzyme A (succinyl-CoA), which then enters the citric acid cycle ( Figure 2 )