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First, on chromosome 8, we identified an associated locus centered on an intronic variant of FAM135B which is associated with smoking behavior 46

It also has a longer half-life, allowing less frequent dosing

Another study reported that the overexpression of isocitrate dehydrogenase in resistant glioma cells could also serve as a biomarker (298)

[DOI] [PubMed] [Google Scholar] 135.Liu Y., Zhou S., Xiang D., Ju L., Shen D., Wang X., Wang Y