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Subsequent studies revealed heightened sensitivity of MM cell lines to ferroptosis, with combined bortezomib and iron chelation exhibiting superior efficacy in suppressing disease progression compared to monotherapy, these findings collectively underscore the critical role of ferroptosis in MM pathogenesis (Figure 3)

An exciting novel avenue to address interindividual variability has appeared with the development of methods to culture human induced pluripotent stem cells (hiPSCs)